Home

A research initiative co-founded by the American Heart Association and Verily, with significant support from AstraZeneca, One Brave Idea was established to pursue unconventional scientific approaches in order to make major advances in the fight against coronary heart disease.

The Burden of Coronary Heart Disease

Cardiovascular disease remains the leading cause of death worldwide, claiming about 17.8 million lives annually. More than eight million of these deaths are caused by coronary heart disease (CHD), which develops when blood flow through the coronary arteries (which supply the heart with oxygen-rich blood) becomes compromised. This is usually the result of plaque buildup and inflammation in the arteries, which can eventually lead to a heart attack.

Over the years, significant progress has been made in our ability to understand, prevent, and treat CHD. However, for many individuals, their first sign of CHD is their heart attack, or even sudden cardiac death. There remains a great need to detect individuals at risk for CHD much earlier and to initiate specific interventions that will prevent heart attacks and other signs and symptoms of CHD.

ONE BRAVE IDEA ANNOUNCES RESEARCH AWARD WINNER

Dr. Calum MacRae, Vice Chair for Scientific Innovation in the Department of Medicine at Brigham and Women’s Hospital in Boston, and his world-class team were selected as the recipients of the One Brave Idea research award.

Latest News and Blog

Dr. Calum MacRae to Become Senior Advisor to BioSymetrics

Dr. Calum MacRae to Become Senior Advisor to BioSymetrics

BioSymetrics, an artificial intelligence and machine learning SaaS company, announces Dr. Calum MacRae as Senior Advisor.  Dr. MacRae is an innovative pioneer in genetics, biology, and drug discovery. Read More
National Wear Red Day

National Wear Red Day

Nearly 80 percent of cardiac events can be prevented, but cardiovascular diseases continue to be a woman's greatest health threat. Read More
Phenotype Phorum | Shaun Coughlin

Phenotype Phorum | Shaun Coughlin

We are committed to bringing together diverse groups of scientists to build a community that embraces meaningful collaborations and forums across academia, industry, and medicine. Read More

Featured Approaches

Deep Phenotyping

Deep Phenotyping

Integrating existing and novel phenotypes across different resolutions—molecular to behavioral—to definitively characterize the transition from wellness to disease. Read More
Genomics + Phenotyping in Clinical Care

Genomics + Phenotyping in Clinical Care

Exploring initial hospitalizations as an opportunity to engage patients and families in rapid-turnaround, genomic studies with the potential to inform acute clinical decision-making. Read More
Engaging Broad Patient Populations in Research

Engaging Broad Patient Populations in Research

Cultivating research interest and participation—in clinics or in daily-life with the advent of remote wearables—from individuals and families across the country. Read More